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It is well known that nicotine, as an agonist of nAChR found in the central and peripheral nervous system, muscle, and many other tissues of many organisms (17), stimulates the nicotinic acetylcholine receptor signaling anti-inflammatory pathway to reduce inflammatory responses, depression, attention deficithyperactivity disorder, cognitive deficits in schizophrenia, Alzheimers disease, and pain (18)

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