B12 injections do not create pharmacological dependency
NHS and NICE guidance on weight management focus on sustainable dietary changes, physical activity, and behavioural support rather than supplement timing
Hoping that Ill notice a difference soon, Ive only done 3 injections (3 weeks) to date
Statistical analysis Assuming a proportion of participants experiencing overcorrection based on previous literature 13,16,21 , we determined that a sample size of 66 participants would yield 80% statistical power to detect a significant difference in the incidence of overcorrection between the proactive and reactive groups, employing an alpha () level of 0.05, beta () of 0.2, and accounting for a 10% dropout rate
However, the transition period may involve temporary irregularities as the body adjusts to new metabolic parameters