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For example, the sustained elevation of pro-inflammatory mediators such as interleukin (IL)-6, tumour necrosis factor alpha (TNF-) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), and transforming growth factor beta (TGF)-1 are likely to accelerate liver fibrosis and cause non-alcoholic steatohepatitis (NASH), a severe condition of NAFLD [14,15,16,17]
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They also overproduce and secrete ECM components, leading to excessive ECM deposition in the myocardial interstitial and gradual replacement of myocardial tissue with fibrosis (249)
General Supplement Spacing Some clinicians recommend a blanket 1- to 2-hour separation between any prescription drug and any dietary supplement