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Shen, D., Ma, S., Li, X

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Importantly, patients with chronic sun exposure or prolonged topical steroid use exhibited focal hypopigmentation (72.22%) and erythema (77.77%), underscoring melanocyte suppression from corticosteroid misuse and UV-aggravated mottling findings with major therapeutic implications

Plants 11, 1497

Research has demonstrated that UA intervention decreases ROS production by inhibiting the activity of NADPH oxidase, a key source of cellular ROS, and subsequently reduces the production of proinflammatory mediators through the regulation of the phosphatidylinositol 3-kinase / protein kinase B / nuclear factor kappa B and c-Jun N-terminal kinase / activator protein 1 signaling pathways (59)