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In addition, combination strategies that enhance doxycycline activity against biofilm-forming pathogens, such as co-administration with N-acetyl-L-cysteine, have shown promising in vitro results (56), and could be explored in future formulations or dosing regimens

2021;97:S616

prior approval withdrawn for business reasons Compoundable in some contexts

Finally, another important free radical is nitric oxide (NO), which is a reactive nitrogen species (RNS) involved in vascularisation, inflammation, and antimicrobial activities in wound healing 59,60,61

In severe cases, aggressive management on ITU is required, whereas those with moderate features need admitting for observation and vital system monitoring until symptoms resolve, with a low threshold for escalating management should there be any early signs of deterioration