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It may help manage blood sugar, reduce heart attack and stroke risk in people with diabetes and known heart disease, and treat kidney problems in diabetic patients

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This highlights a potential role for mitochondrial ROS in modulating immune responses and contributing to conditions like mast cell activation syndrome (MCAS) seen in hEDS (Figure 2

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Thus, there is inadequate data in this generally-young cohort to suggest alternative management based on adult age, although there may be a higher rate of intolerance to amitriptyline in adults than in children over age 5