Chromium picolinate - Promotes a balanced blood glucose response
doi: 10.1097/00004850-200008002-00002 114
Some need a doctors prescription but are otherwise widely available (e.g., GLP-1 RAs like semaglutide and tirzepatide)
Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]
Abstract Background Medications targeting the glucagon-like peptide-1 (GLP-1) pathway are an important therapeutic class currently used for the treatment of Type 2 diabetes (T2D)