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Bateup, H

found enhanced uptake of SARS-CoV and S-expressing pseudoviruses into monocyte-derived macrophages mediated by FcRIIa and anti-S serum antibodies 32

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Interestingly, Tajimas D statistical analysis indicated positive selection in European populations, suggesting this gene may have played an essential evolutionary role in this region

Future strategies must involve more selective senolytics, senomorphics to suppress harmful SASP factors, or targeting upstream triggers like iron overload that drive pathological senescence