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Combination therapy with a dipeptidyl peptidase-4 (DPP-4) inhibitor, such as sitagliptin (Januvia, Merck), may be considered, especially as evidence of its safety and efficacy has become available

Most preclinical studies are conducted in young, healthy, genetically homogeneous male rodents, far removed from the heterogeneity of aging human populations with comorbidities such as hypertension, diabetes, or cerebrovascular disease

The dual nature of free radicals plays a crucial role in human physiology and pathology

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%)