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Results Selected genes and proteins associated with the skin barrier function The results showed that filaggrin and loricrin were significantly upregulated in the skin of smokers at both the gene expression and protein levels (Fig

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All data was analyzed using GraphPad Prism 8 software

But the Royal College of Physicians has previously called for the devices to be made more widely available, arguing smokers should be moved on to safer substitutes such as e-cigarettes to supplement therapeutic approaches using nicotine patches and gum