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Safety Profile The safety profile of orforglipron across its Phase 2 and Phase 3 clinical development program has been consistent with the established safety characteristics of the GLP-1 receptor agonist class

As a result, adenosine uptake is reduced, and its concentration in the plasma increases

In the STEP 1 trial with 1,961 participants, patients taking 2.4 mg semaglutide weekly alongside reduced caloric intake and increased physical activity lost an average of 14.9% of their body weight over 68 weeks

The burden of diabetes-associated multiple long-term conditions on years of life spent and lost