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Mauro Maccarrone (Professor) (2015) Endocannabinoid signaling in female reproductive events: a potential therapeutic target?, Expert Opinion on Therapeutic Targets, 19:11, 1423-1427, DOI: 10.1517/14728222.2015.1062878 Metz, T

Black pepper and white pepper notes create a tingling sensation, especially when smoke passes through the nasal passages

This extremely high and anxiogenic value got the attention of the media and has been applied everywhere since then without much thought, with an equivalence to air pollution of 1 cigarette = 22 g/m3

When this is figured out for the tobacco category, it will become a far stronger sales opportunity for the industry