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In September 2019, FDA announced that it would finalize this guidance document "in the coming weeks," with the intention of clearing "the market of flavored e-cigarettes to reverse the deeply concerning epidemic of youth e-cigarette use." 211 Delays in guidance finalization led to a Congressional hearing on December 4, 2019 to investigate the cause for delay

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A 2016 study published in the Journal of Caffeine Research found that young adults ages 18-28 who consumed energy drinks weekly were also more likely to have misused alcohol and drugs in the last 30 days