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The numbers speak clearly

More Insulin Sensitive: It is likely that a person will be more sensitive to increases and decreases in insulin levels when eating, leading to a greater likelihood of fat accumulation over time

Preclinical pharmacoscintigraphic imaging and studies in canine models have demonstrated that semaglutide is primarily absorbed in the stomach, with higher drug concentrations detected in the splenic vein relative to the portal vein, indicating site-specific uptake [51]

Frontiers in Endocrinology

While GLP-1 RAs have provided an important new weapon for those suffering from profound obesity, they unfortunately trigger the same counter-productive mechanisms as other weight-loss efforts, which rely on caloric restriction, resulting in muscle loss, which limits the fat loss and metabolic benefit