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53 Although dementia was not a primary outcome, a pooled analysis of 15,820 patients with type 2 diabetes randomised to GLP-1 receptor agonist treatment or placebo found a 50% reduction in dementia progression over a median of 3.6 years (15 cases in the placebo group vs 32 in the GLP-1 receptor agonist group)

Other AEs reported with SGLT2i use include osmotic diuresis-related events and volume depletion-related hypotension, the latter of which tends to be more common in older adults, people with an eGFR of 3060 mL/min/1.73 m 2 , and in those taking loop diuretics [4]

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