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The relationship between semaglutide dosage and appetite suppression follows a dose-response curve, but individual variability significantly affects outcomes

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At the 12mg dose in TRIUMPH-1: Average weight loss of 28.3% at 80 weeks within the range of bariatric surgery outcomes 45.3% of participants lost 30% or more the threshold associated with bariatric surgery in published literature 65.3% achieved BMI below 30 no longer classifiable as obese by standard criteria Extension data to 104 weeks shows 30.3% average continuing to approach surgical outcomes with longer treatment The comparison is not a simple equivalence

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