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When they got up in the mornings the youths had no work to do and nowhere to go except the street corner, where they sat or sprawled on the pavement, gossiped, wrestled, grumbled

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The transition to a more severe expression of smoking-associated disease is marked by the impaired ability of macrophages to kill bacteria or viruses, the loss of ability to remove dead cells, the degradation and chemical modification of the extracellular matrix, the increasing retention of oligoclonally expanded CD8+ T cells and the induction of interleukin-17-secreting effector T cells