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The search strategy included combinations of MeSH terms and free-text terms such as GLP-1 receptor agonists, insulin resistance, major depressive disorder, bipolar disorder, mood disorders, neuroinflammation, and reward system. Articles published in English were considered, and we included clinical trials, observational studies, systematic and narrative reviews, meta-analyses, preclinical animal studies, and cellular models relevant to GLP-1 RAs in the context of psychiatric and metabolic disorders