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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

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Grey applauds the latest approach: "The ATU's work is a key part of our strategy to tackle smoking, as it's trying to stop young people from starting and helping adults to quit." But she is more pragmatic than fellow Liverpudlian Andy Burnham, the health secretary, who last week said he wants to see smoking down to 10% of the population by 2020