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A systematic review and meta-analysis performed in 2011 on 13,800 cancer patients and 23,340 healthy controls reported that adherence to the MedDiet was related to a reduced risk of death from cancer and specifically that the regular consumption of olive oil may reduce the probability of cancer ( A 2013 Cochrane review performed on 52,044 randomized participants showed limited positive effects of the MedDiet on cardiovascular risk ( More recently, a huge umbrella review conducted on more than 12,800,000 subjects from 29 meta-analyses demonstrated a robust statistical association between adherence to the MedDiet and risk reduction of cardiovascular and neurodegenerative diseases, cancer incidence and diabetes (Figure 3)
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