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Subgroup analysis by study design showed that the pooled OR of cohort studies was unadjusted 1.18 (95% CI: 0.961.44, I 2 =77%, p=0.11) and adjusted 1.18 (0.96-1.44, I 2 =77%, p=0.11), while that of case-control studies was unadjusted 1.12 (95% CI: 1.031.21, I 2 =28%, p=0.005) and adjusted 1.10 (95% CI: 1.001.20, I 2 =34%, p=0.05)

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While a recent cohort study demonstrated a significant trend of increasing stroke risk with younger age at smoking initiation over a ten-year follow-up 25 , no such association with stroke was identified in a birth cohort followed up for five decades 26

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