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In comparison, Lillys own triple-G competitor retatrutide showed around 17.5% weight loss in a Phase 2 study, according to BMO

Persistent lymphadenopathy (3 weeks for neck lumps) requires GP assessment and may warrant suspected cancer pathway referral per NICE NG12

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Patients who gained weight while prescribed any of the GLP-1 medications studied had no statistically significant change in their TSH levels

Quick Answer: Semaglutide mimics one hormone (GLP-1) to reduce appetite, while tirzepatide mimics two hormones (GLP-1 and GIP) to potentially provide even stronger metabolic support