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Thyroid hormones exhibit profound metabolic effects characterized by an increased rate of both catabolic and anabolic reactions, resulting in an overall acceleration of the basal metabolism which is associated with increased oxygen consumption, respiratory rate, energy expenditure, and heat production (56)
Preclinical studies suggest that statins can reduce BBB permeability by enhancing the expression of tight junction proteins and decreasing the activity of MMPs, which are implicated in the degradation of tight junctions (Liu et al., 2021)
Receptor-mediated endocytosis is also known as clathrin-dependent endocytosis as the membrane-associated protein clathrin takes part in forming membrane vesicles that become internalized into the cell (32)
Cellular senescence: from mechanisms to current biomarkers and senotherapies
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