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In 2010, the Food and Drug Administration (FDA) issued warning letters to manufacturers citing "violations of good manufacturing practices, making unsubstantiated drug claims, and using the devices as delivery mechanisms for active pharmaceutical ingredients." They also mentioned, however, that the effects of e-cigarettes are unclear, and included a phone number for people to report any adverse events

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These include ADHD and dementia and Alzheimers Disease

2, the agency issued enforcement guidance alerting companies that manufacture, distribute, and sell unauthorized flavored cartridge-based e-cigarettes within the next 30 days will risk FDA enforcement action