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This technique has already been used previously to analyze the effectiveness of anti-smoking laws 18 , since it provides some advantages that can be summarized as: 1) it considers the average of the complete sample and measures its relative convergence, 2) it takes into account heterogeneities, which are based in a non-linear time-varying factorial model, 3) it considers heterogeneities, which depends on a non-linear time-varying factorial model, 4) it is robust to the unit root properties of the series, 5) the results are unbiased and consistent, and 6) eliminates the need for an ex-ante sample separation since it has a new algorithm based on data to determine the clusters of the subgroups of convergence

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Human studies and mouse models support the role of the gut microbiome in predisposition to RA, such as reduction in bacteria belonging to the family Bifidobacterium and Bacteroides [181], and higher prevalence Prevotella copri [182]