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Cigarette smoke contains several toxic compounds that contribute to the pathogenesis of many respiratory diseases, such as COPD and lung cancer [4]
On the other hand, patients who stop smoking have a reduced risk of flare-ups or reoperation for recurrence with less use of maintenance therapy compared to continuing smokers 3
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We observe five genome-wide significant loci, including previously unreported loci MAGI2/GNAI1 (rs2714700) and TENM2 (rs1862416), and extend loci reported for other smoking traits to nicotine dependence
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