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In the above reaction, Glutathione Peroxidase is the rate-limiting step of the entire reaction system, so the decrease in NADPH is linearly related to the activity of Glutathione Peroxidase

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The charged trimethylamine and carboxyl groups on L-carnitine facilitate interaction with the corresponding poles on membrane phospholipids, glycolipids, and proteins (23, 24)

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Several large clinical studies, the majority of which are cardiovascular outcome trials, indicate that GLP-1 RA therapy is safe and tolerable for people living with T2DM and compromised renal function, and also suggest that GLP-1 RAs may have renoprotective properties

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