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Stage Two: Genetic Alterations Carcinogenic substances such as nitrosamines, polycyclic aromatic hydrocarbons (PAHs), and formaldehyde cause mutations in oncogenes and tumor suppressors (e.g., p53) present in the DNA of the mouth's lining

If you make, modify, mix, manufacture, fabricate, assemble, process, label, repack, relabel, or import smokeless tobacco, you must comply with these requirements for manufacturers

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Also, there will be some charred dust spread across the leaf, so having a cloth or damp towel to wipe it down is convenient