Some e-cigarette litigation has been consolidated into multidistrict litigation proceedings in federal court, where individual cases from across the country are grouped for coordinated pretrial proceedings but remain separate individual claims
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14) that can signal the release of neurotransmitters such as dopamine, norepinephrine, acetylcholine, GABA, and glutamate involved in reward pathways, transmission at the neuromuscular junction, and cognition (Figures 2, 3) [Figure 2) [ FIGURE 2 FIGURE 3 Brain imaging studies have demonstrated that nicotine acutely increases the activity in the visual system, PFC, and thalamus which are consistent with activation of the corticobasal ganglia-thalamic brain circuits [Figure 4) [ FIGURE 4 While electronic cigarettes (e-cigarettes) do not produce combusted smoke, they do deliver an aerosol containing nicotine and other tobacco-related compounds [ Prenatal and early postnatal development Nicotinic acetylcholine receptors (nAChRs) From gestation to adulthood, nAChRs have been shown to play a functionally distinct role in the development of the brain through the modulation of neurotransmitter release across neurodevelopmental stages [ Literature has documented that exposure to nicotine during fetal development has adverse effects on the developing offspring [Figure 4) [ Brain volume and characteristics Gestational nicotine has also been shown to decrease the total number of cells in the whole brain and in certain neuronal subregions during the early fetal and neonatal period [ Hypothalamic-pituitary-adrenal (HPA) axis The fetal hypothalamic-pituitary-adrenal (HPA) axis is critical for mechanisms controlling the regulation of intrauterine homeostasis, the timely differentiation and maturation of vital organ systems such as the CNS, liver, and lungs, preparing the timing of fetal growth, and commencing parturition [ Epigenetics Maternal smoking in pregnancy has also been associated with epigenetic modifications, including DNA methylation, that are implicated in deleterious changes to gene expression and processes related to growth and development [ n = 6,685) [ DGLAP2 belongs to a gene family that encodes proteins that are involved in the molecular organization of synapses and in neuronal cell signaling and has been associated with progressive epilepsy with intellectual disabilities along with other CNS disorders such as ASD and schizophrenia [ Neurobehavioral and neurodevelopmental effects Attention-deficit hyperactivity disorder (ADHD) Attention-Deficit Hyperactivity Disorder (ADHD) is a clinically heterogenous neurodevelopmental disorder characterized by hyperactivity, inattention, impulsiveness, and inattention that first presents during childhood [ ADHD significantly impairs multiple aspects of life and has been associated with unsuccessful marriage, educational underachievement, unemployment, criminality, etc
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