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The presence of melatonin in these organelles is likely of special importance when there is a rapid deluge of newly produced radicals such as occurs during exposure to ionizing radiation (94), injurious chemicals such as paraquat (95), or toxic drugs such as including chemotherapies (96)

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These physiological and molecular responses were accompanied by activation of genes related to cutin, suberine, and wax biosynthesis, as well as modulation of cytokinin and brassinosteroid metabolism

doi: 10.3390/nu15173728 83 CummingsDEOverduinJ

Subsequent studies have shown that it can influence melatonin secretion, a key regulator of circadian rhythms and sleep-wake cycles