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Abnormal activation of TLRs leads to an exaggerated autoimmune response with increased production of cytokines such as IL17A and IL22, which are responsible for hyperproliferation and abnormal differentiation of keratinocytes, ultimately leading to the formation of psoriatic plaques (Sun et al., 2019)

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Like its musical numberswhich may begin as diegetic radio broadcasts, then become characters singing along to a record, and might end with lip-synching or dancingthe film, in trying to juggle five different genres at once, winds up being none of those genres in a completely satisfying manner

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