Among the identified metabolites, only Ac-LKKTE exhibited in vitro wound healing activity, indicating that previous functional effects attributed to TB-500 may be due to this specific metabolite (Rahaman et al
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Human studies using Lactobacillus as a probiotic have often demonstrated decreased body weight and/or body fat in a strain-dependent manner (for a review of human studies, see Crovesy et al., 2017 58 ), suggesting that the NNMTi-and-LD-mediated changes to Lactobacillus relative abundance may be critical to NNMTi-mediated weight loss
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(10) In cell cultures of fibroblasts, which are the main type of cell producing collagen in tissues, including ligaments, the peptide appeared to markedly support fibroblast outgrowth, migration, and spreading