cigarette smoke and adverse health effects of Smoking on Your Body You don't have to smoke

Ads for the Half and Half mixture and telescoping tin can be found in newspapers from 1936, I do not know if they predate the ads by any time

(patent) : English translation: What Are The Famous "Herzegovina Flor" Cigarettes And Why They Are So Named :

National Institute on Drug Abuse, Food and Drug Administration, & Center for Tobacco Products

An ad for ketchup in the 1950s used the headline, You mean a woman could open it? next to a bemused female caricature

Due to how frequent these changes happened, the transition stopped becoming seamless and often felt like they were cutting into scenes we hoped would be longer