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By sequestering these metal ions, catechins prevent the formation of hydroxyl radicals, thereby reducing oxidative stress

This review integrates preclinical research related to the effects of both stress and antidepressant treatment on synaptic plasticity, and proposes normalization of synaptic function as a final common pathway for depression treatment

Other side-effects include vomiting, diarrhoea, stomach pain, neurologic adverse events (dizziness, seizures, confusion), sudden drop in blood pressure, severe skin rash potentially requiring hospitalisation, and liver injury (hepatitis)

In a study published in the American Journal of Physiology-Endocrinology and Metabolism , Van der Heyden et al