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So brilliantly does he compensate for his disability, even his wife will forget and say, "Will you hang that picture?" Senator Alan Simpson, another tall, blunt, irreverent wit, who has been in the trenches with Dole on deficit busting and tax reform, shakes his head in unaccustomed awe when asked about Bob Dole

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"The quick answer to that is no," said Thomas Glynn, director of cancer science and trends at the American Cancer Society

There are many factors involved: your tolerance to caffeine, whether you have other conditions (irritable bowel syndrome, heartburn), what kind of coffee you drink, and so on