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The purinergic receptor family, including P2Y 12 (involved in microglial chemotaxis) and P2X 7 (which activates the inflammasome), is also being actively investigated as a potential pharmacological target [488, 489]

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Choi O., Kim J., Kim J.G., Jeong Y., Moon J.S., Park C.S., Hwang I

Novo Nordisk and Eli Lilly have been slower to pursue addiction indications for the medicines, while running trials proving their cardiovascular benefits, effects on kidney disease, heart failure and sleep apnea

S1P is associated with inflammation, immunity, and insulin resistance and has also been associated with the development of obesity and T2D (129)