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Nicotine from chewing tobacco may promote insulin resistance, which is a key driver of fat accumulation in the liver

Nicotine belongs to a family of compounds called alkaloids and occurs naturally in several varieties of plant, including tomatoes, aubergines and potatoes, but is found at its highest levels in the tobacco plant

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However, the route, speed and amount of nicotine absorption (and subsequent nicotine levels in plasma) are important determinants of the efficacy of ECs to serve as smoking substitutes and of any concerns about nicotine overdose or intoxication