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In contrast, CHAC2 possesses lower efficiency and was initially thought to be constitutively expressed (Kaur et al., 2017)

Patients should be referred urgently if they have neurological symptoms, if the diagnosis is unclear, or if there is inadequate clinical response to treatment

Amino acids of proteins are targets of HO, which can cause the inactivation of the active site of enzymatic proteins

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For example, acyl and free carnitine serum concentrations are, respectively, 12.8 7.4 and 67 21.8 mol/L [17] and circulating carnitine accounts for only about 0.5% of body carnitine [18]