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He noted that exposed and non-exposed patient groups were not adequately stratified by baseline AMD severity, potentially biasing the findings

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Medical Pharmacology Chapter 2: General Principles: Pharmacokinetics Cytochrome P450 Enzyme Induction: Following repeated administration, some drugs increase the amount of P450 enzyme usually by: Increase enzyme synthesis rate (induction) Reduced enzyme degradation rate Cytochrome P450 enzyme inhibition: Certain drugs, by binding to the cytochrome component, act to competitively inhibit metabolism

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doi: 10.1016/j.jpain.2016.11.004 94