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Anecdotally, glycine can reduce acute and generalized anxiety

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Simultaneously, the cartilages characteristic hypoxic microenvironment promotes the stabilization of hypoxia-inducible factors (HIF-1 and HIF-2), driving transcriptional programs that support collagen type II and proteoglycan synthesis and inhibiting angiogenesis, thus preserving the low-oxygen milieu optimal for chondrocyte function

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