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Whilst older thiazide diuretics at higher doses have been associated with erectile problems in some studies, the evidence is mixed and may be dose- and agent-dependent

Alongside the market analysis, a Phase I/IIa case study details how an adaptive first-in-human study design, covering 116 healthy adults with BMI 27 to 38, achieved 11.3% placebo-adjusted weight reduction at 1.2 mg, with no serious adverse events and a six-month reduction in IND-enabling timelines

Besednova, N.N., Zaporozhets, T.S., Kuznetsova, T.A., Kryzhanovski, S.P., Kovalev, N.N

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tirzepatide and retatrutide, respectively)