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Neurochem Res 48 , 23352344 (2023)

Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (36, 83)

[DOI] [PubMed] [Google Scholar] 223.Wertz PW

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May your receptors stay responsive, your titrations stay gradual, and your research stay evidence-based.