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Importantly, however, most of these studies have investigated only short-term effects [10, 14, 15, 22, 27,28,29, 31, 32], and the long-term effects of e-cigarette consumption on human health are still unclear and require further study

Therefore, the present study harnesses the power of a population-based cohort to elucidate the significance of early age at smoking initiation as a potential independent risk factor for cardiovascular outcomes

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