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(01:02) Such was the zeitgeist power of Virginia Slims that they became the very last cigarette brand ever advertised on American TV, at 11:59 p.m on January 2, 1971, during The Tonight Show Starring Johnny Carson

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Aetiology History Clinical findings Images Aetiology While there are many causes of vesicles and bullae, it is the immunobullous conditions, and epidermolysis bullosa, which commonly provoke most interest due to their dramatic impact on the patient and their relatives Immunobullous conditions These are characterised by pathogenic autoantibodies directed at target antigens whose function is either cell-to-cell adhesion within the epidermis or adhesion of stratified squamous epithelium to dermis or mesenchyme