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[92] The Royal College of General Practitioners stated in 2016 that "To date 42 chemicals have been detected in ENDS aerosol though with the ENDS market being unregulated there is significant variation between devices and brands." [93] E-liquid nicotine concentrations vary

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In South Korea, especially after the COVID-19 pandemic, there has been a high preference for HTPs, and the sales volume of HTPs in 2021 reached 210 million packs, an increase of 16.3% compared to the previous year

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