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Research suggests that metformin can reduce vitamin B12 absorption in the digestive tract, potentially leading to lower B12 levels over time

131 In addition, gene polymorphisms can alter astrocyte responses to pathologies and contribute to disorder progression, as for example with APOE polymorphisms in AD or traumatic injuries, 132,133,134,135 or with CD38 polymorphisms in PD

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Addressing gut health at the structural level allows for more lasting improvements compared to symptom-based approaches

This finding aligns with earlier studies that reported a combination of green tea and vitamin E reduced CK-MB activity, lipid peroxidation, and heart weight in ISO-induced myocardial infarction in rats 29