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Patients receiving inulin experienced greater weight loss and additional improvements, including reduced diastolic blood pressure, lower AST levels, and decreased insulin levels

Additionally, Lactobacillus and Bifidobacterium species produce GABA through enzymatic glutamate decarboxylation [186]

Moreover, patients without preexisting conditions, such as moderate-to-severe CKD and chronic ischemic heart disease, showed more pronounced risk reductions (HR = 0.69 and HR = 0.66, respectively) than their counterparts (HR = 0.75 and HR = 0.80, respectively)

This is significant because it is the natural site of action of the GLP1-RAs and most relevant to their uses in diabetes and appetite control

Pseudoallergic reactions in chronic urticaria are associated with altered gastroduodenal permeability