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September, 2014 E-Cigarettes: The Best and the Worst Case Scenarios for Public Health. September 9

And forgive me if I have made this next point already

At some point I just realised that I hadn't smoked for many days

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Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers