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Oral trauma Hormonal changes related to the menstrual cycle Anxiety or stress Smoking cessation Heredity Drugs (including anti-inflammatory drugs, such as ibuprofen [Motrin, Advil], and beta-blockers, such as atenolol [Tenormin]) Food allergies or sensitivities (chocolate, tomatoes, nuts, and acidic foods such as pineapple, and preservatives such as benzoic acid and cinnamaldehyde) Toothpastes containing sodium lauryl sulfate Deficiencies of iron, folic acid, or vitamin B12 (although supplementation with iron or vitamins has not been shown to increase the likelihood of ulcer resolution) Some studies have suggested an association with Helicobacter pylori , the same bacteria that cause peptic ulcers

They were (are) all fond of smoking

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This increased prevalence is often explained in terms of the cognitive self-medication hypothesis, which posits that individuals with schizophrenia start and maintain tobacco use for its ameliorating effects on some of their cognitive deficits, particularly attentional deficits (Ziedonis et al., 2008