Int J Clin Exp Pathol 3(6):570581 Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL et al (2003) American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
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Proc Natl Acad Sci USA 106 , 40124017 (2009)
It also promotes apoptosis through upregulation of p53-dependent pathways and cell cycle arrest at G1 phase, mediated by modulation of key downstream targets, such as FoxO1, miR-215, miR-96, CD44, survivin, and VEGF, thereby limiting tumor survival and metastasis 165
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